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They found that the five-HT3 receptor antagonist MDL72222 alone was ready to attenuate this impact Virtually up to the overall serotonin antagonist methysergide, indicating that modafinil labored to decrease GABA partly by way of a serotonergic pathway mediated mostly from the 5-HT3 receptor.But one of the better experiments to this point looked at

Even so, pretreatment with corticosterone or dexamethasone mitigated the impact of stress on modafinil’s movement outcomes. The authors remark that these effects aid the hypothesis that pressure desensitizes or inhibits αone adrenoreceptors and corticosterone pretreatment attenuates this outcome, though the exact system of this outcome was not v